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Ishizaka, T. et al.

Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and its expression in various tissues.

Interleukin-18 ( IL-18) is a cytokine with potent interferon-gamma-inducing activity, and plays an important biologic role in the enhancement of the activity of natural killer cells and cytotoxic T-lymphocytes. In this study, feline IL-18 cDNA was cloned and characterized to establish a basis for the prospective cytokine therapy in small animal practice. The nucleotide sequence of feline IL-18 cDNA obtained in this study was 712bp long and contained its entire open reading frame encoding 192 amino acid residues. The predicted amino acid sequence of feline IL-18 cDNA showed 77.2, 84.8, 60.2 and 62.6% similarity with those of human, dog, rat and mouse counterparts, respectively. The feline IL-18 cDNA included a putative cleavage site of IL-1beta-converting enzyme (ICE) and IL-1 signature-like sequences identified in human and mouse IL-18 cDNAs. Expression of IL-18 mRNA was detected in various tissues including spleen, liver and cerebrum in the cat.[1]

References

Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and its expression in various tissues. Ishizaka, T., Setoguchi, A., Masuda, K., Ohno, K., Tsujimoto, H. Vet. Immunol. Immunopathol. (2001) [Pubmed]

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