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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Neisseria gonorrhoeae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase does not catalyze the formation of the ribo analogue.

[figure: see text] Neisseria gonorrhoeae 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH 7-P) synthase catalyzes an aldol-type condensation between D-erythrose 4-phosphate and phosphoenolpyruvate (PEP) to form 3-deoxy-D-arabino-heptulosonate 7-phosphate and not 3-deoxy-D-riboheptulosonate 7-phosphate. Similar to the Escherichia coli enzyme, N. gonorrhoeae DAH 7-P synthase condenses D-arabinose 5-phosphate with PEP to give 3-deoxy-D-manno-octulosonate 8-phosphate. Therefore, the stereochemistry of the reaction catalyzed by N. gonorrhoeae DAH 7-P synthase at C1 of the phosphorylated monosaccharide is the same as that for the E. coli enzyme, namely, re face attack.[1]

References

  1. Neisseria gonorrhoeae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase does not catalyze the formation of the ribo analogue. Sundaram, A.K., Woodard, R.W. Org. Lett. (2001) [Pubmed]
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