Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.
The XMAP215/ch-TOG/Msps family of microtubule-associated proteins (MAPs) promote microtubule growth in vitro and are concentrated at centrosomes in vivo. We show here that Msps (mini-spindles protein) interacts with the centrosomal protein D-TACC, and that this interaction strongly influences microtubule behaviour in Drosophila embryos. If D-TACC levels are reduced, Msps does not concentrate at the centrosomes efficiently and the centrosomal microtubules appear to be destabilized. If D-TACC levels are increased, both D-TACC and Msps accumulate around the centrosomes/spindle poles, and the centrosomal microtubules appear to be stabilized. We show that the interaction between D-TACC and Msps is evolutionarily conserved. We propose that D-TACC and Msps normally cooperate to stabilize centrosomal microtubules by binding to their minus ends and binding to their plus ends as they grow out from the centrosome.[1]References
- Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour. Lee, M.J., Gergely, F., Jeffers, K., Peak-Chew, S.Y., Raff, J.W. Nat. Cell Biol. (2001) [Pubmed]
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