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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

Dichloroacetate (DCA) stimulates pyruvate dehydrogenase complex (PDHC) activity and lowers cerebral lactate concentrations. In the R6/2 and N171-82Q transgenic mouse models of Huntington's disease ( HD), DCA significantly increased survival, improved motor function, delayed loss of body weight, attenuated the development of striatal neuron atrophy, and prevented diabetes. The percentage of PDHC in the active form was significantly reduced in R6/2 mice at 12 weeks of age, and DCA ameliorated the deficit. These results provide further evidence for a role of energy dysfunction in HD pathogenesis and suggest that DCA may exert therapeutic benefits in HD.[1]

References

  1. Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Andreassen, O.A., Ferrante, R.J., Huang, H.M., Dedeoglu, A., Park, L., Ferrante, K.L., Kwon, J., Borchelt, D.R., Ross, C.A., Gibson, G.E., Beal, M.F. Ann. Neurol. (2001) [Pubmed]
 
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