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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

M1 receptor activation is a requirement for arecoline analgesia.

Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.). A dose-dependent inhibition of the antinociception induced by arecoline was observed after inactivation of the M1 gene by an antisense oligodeoxyribonucleotide (aODN). This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors.[1]


  1. M1 receptor activation is a requirement for arecoline analgesia. Ghelardini, C., Galeotti, N., Lelli, C., Bartolini, A. Farmaco (2001) [Pubmed]
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