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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans.

An early event in RNA interference (RNAi) is the cleavage of the initiating double-stranded RNA (dsRNA) to short pieces, 21 to 23 nucleotides in length. Here we describe a null mutation in dicer-1 (dcr-1), a gene proposed to encode the enzyme that generates these short RNAs. We find that dcr-1(-/-) animals have defects in RNAi under some, but not all, conditions. Mutant animals have germ line defects that lead to sterility, suggesting that cleavage of dsRNA to short pieces is a requisite event in normal development.[1]

References

  1. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Knight, S.W., Bass, B.L. Science (2001) [Pubmed]
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