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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Diagnosis of HAM/ TSP based on CSF proviral HTLV-I DNA and HTLV-I antibody index.

The contribution of human T-cell lymphotropic virus (HTLV-I) DNA by PCR in CSF and the intrathecal synthesis of antibodies to HTLV-I by the antibody index (AI) to the diagnosis of HTLV-1- associated myelopathy (HAM)/tropical spastic paraparesis ( TSP) were evaluated. Cases of spastic paraparesis compatible with HAM/ TSP had increased AI for HTLV-I (60/73) and HTLV-I proviral sequences in CSF (25/27). Among 27 patients with other neurologic diseases, three had increased AI and another three had positive HTLV-I DNA in CSF. Thus, the combination of PCR for proviral DNA and AI for HTLV-I in CSF provides consistent criteria for the diagnosis of HAM/ TSP.[1]

References

  1. Diagnosis of HAM/TSP based on CSF proviral HTLV-I DNA and HTLV-I antibody index. Puccioni-Sohler, M., Rios, M., Carvalho, S.M., Gonçalves, R.R., Oliveira, C., Correa, R.B., Novis, S., de Oliveira, M.S., Bianco, C. Neurology (2001) [Pubmed]
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