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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons.

The dendritic arbor of pyramidal neurons is not a monolithic structure. We show here that the excitability of terminal apical dendrites differs from that of the apical trunk. In response to fluorescence-guided focal photolysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none responses that were subthreshold for somatic action potentials. Calcium transients produced by all-or-none responses were not restricted to the sites of photolysis, but occurred throughout individual distal dendritic compartments, indicating that electrogenesis is mediated primarily by voltage-gated calcium channels. Compartmentalized and binary behavior of parallel-connected terminal dendrites can greatly expand the computational power of a single neuron.[1]

References

  1. Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Wei, D.S., Mei, Y.A., Bagal, A., Kao, J.P., Thompson, S.M., Tang, C.M. Science (2001) [Pubmed]
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