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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Significant overexpression of oligophrenin-1 in colorectal tumors detected by cDNA microarray analysis.

The human oligophrenin-1 gene is ubiquitously expressed at low levels and expressed at high levels in the developing neuroepithelium of the neural tube. Mutations in this gene have been related to the X-linked mental retardation. Using cDNA microarrays, we found evidence that oligophrenin-1 is strongly up-regulated in colorectal tumors. Semiquantitative reverse transcriptase polymerase chain reaction confirmed this finding. Thus, a well-known nervous system-associated human gene transcript may also be an important colorectal tumor marker and potential therapeutic target.[1]

References

  1. Significant overexpression of oligophrenin-1 in colorectal tumors detected by cDNA microarray analysis. Pinheiro, N.A., Caballero, O.L., Soares, F., Reis, L.F., Simpson, A.J. Cancer Lett. (2001) [Pubmed]
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