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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.

We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of beta-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.[1]

References

  1. Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin. Shimizu, M., Shiota, S., Mizushima, T., Ito, H., Hatano, T., Yoshida, T., Tsuchiya, T. Antimicrob. Agents Chemother. (2001) [Pubmed]
 
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