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Tsotinis, A. et al.

Tsotinis, Panoussopoulou, Sivananthan, Sugden,

Synthesis of new tricyclic melatoninergic ligands.

We report the synthesis and biological evaluation of a series of new tricyclic analogs of the hormone melatonin, which act as probes of the constraints at the hormone's receptor site with regard to the lower N1-C2 region of the indole moiety of melatonin. Three of the new compounds, N-[2-(2-methoxy-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)ethyl]acetamide (9), and the respective propionamide 10 and butyramide 11, are as potent as melatonin in the Xenopus laevis melanophore model.[1]

References

Synthesis of new tricyclic melatoninergic ligands. Tsotinis, A., Panoussopoulou, M., Sivananthan, S., Sugden, D. Farmaco (2001) [Pubmed]

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