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Analgesic sesquiterpene dilactone from Mikania cordata.

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.[1]


  1. Analgesic sesquiterpene dilactone from Mikania cordata. Ahmed, M., Rahman, M.T., Alimuzzaman, M., Shilpi, J.A. Fitoterapia (2001) [Pubmed]
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