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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.

Degradation of SnoN is thought to play an important role in the transactivation of TGF-beta responsive genes. We demonstrate that the anaphase-promoting complex (APC) is a ubiquitin ligase required for the destruction of SnoN and that the APC pathway is regulated by TGF-beta. The destruction box of SnoN is required for its degradation in response to TGF-beta signaling. Furthermore, the APC activator CDH1 and Smad3 synergistically regulate SnoN degradation. Under these circumstances, CDH1 forms a quaternary complex with SnoN, Smad3, and APC. These results suggest that APC(CDH1) and SnoN play central roles in regulating growth through the TGF-beta signaling system.[1]

References

  1. The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Wan, Y., Liu, X., Kirschner, M.W. Mol. Cell (2001) [Pubmed]
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