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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.

Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.[1]

References

  1. Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration. Ostrovskaya, R.U., Mirsoev, T.K., Romanova, G.A., Gudasheva, T.A., Kravchenko, E.V., Trofimov, C.C., Voronina, T.A., Seredenin, S.B. Bull. Exp. Biol. Med. (2001) [Pubmed]
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