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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Beta-lactam modification of the bacteraemic profile and its relationship with mortality in a pneumococcal mouse sepsis model.

A sepsis BALB/c mice model was used to investigate the relationship between mortality and the bacteraemic profile produced by a serotype 6B Streptococcus pneumoniae clinical isolate (MIC/ MBC of amoxicillin 4/4 mg/L and of cefotaxime 2/4 mg/L). Animals were treated subcutaneously with doses of amoxicillin or cefotaxime ranging from 6.25 to 50 mg/kg tds for 48 h, starting 1 h after intraperitoneal inoculation (2 x 10(7) cfu/mouse). Blood cultures were carried out daily over 15 days. A survival rate of 100% was obtained with amoxicillin 25 mg/kg and of 60% with cefotaxime 50 mg/kg. A statistically significant (P = 0.012) relationship was found between the maximum cfu/mL in blood and mortality. A maximum log cfu/mL of 6.5 was associated with an 84% probability of death.[1]

References

  1. Beta-lactam modification of the bacteraemic profile and its relationship with mortality in a pneumococcal mouse sepsis model. Yuste, J., Jado, I., Fenoll, A., Aguilar, L., Giménez, M.J., Casal, J. J. Antimicrob. Chemother. (2002) [Pubmed]
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