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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ambroxol inhibits platelet-derived growth factor production in human monocytic cells.

Several growth factors, including platelet-derived growth factor (PDGF), have been implicated in the mechanism of lung and airway remodeling. We investigated the effect of ambroxol, trans-4-[(2-amino-3,5-dibromobenzyl) amino] cyclohexanol hydrochloride, on the lipopolysaccharide-induced PDGF production in human monocytic cells, THP-1. Ambroxol inhibited the lipopolysaccharide-induced PDGF-AB production via PDGF-A mRNA expression. Lipopolysaccharide activated p44/42 extracellular signal-regulated kinase ( ERK), and ambroxol attenuated the lipopolysaccharide-induced p44/42 ERK activation. Furthermore, mitogen-activated protein kinase kinase (MEK)-1-specific inhibitor, 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD 98059), blocked the lipopolysaccharide-induced p44/42 ERK activation and PDGF production. These findings indicate that ambroxol inhibits the lipopolysaccharide-induced PDGF production due to the suppression of p44/42 ERK activity.[1]


  1. Ambroxol inhibits platelet-derived growth factor production in human monocytic cells. Utsugi, M., Dobashi, K., Koga, Y., Masubuchi, K., Shimizu, Y., Endou, K., Nakazawa, T., Mori, M. Eur. J. Pharmacol. (2002) [Pubmed]
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