Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Baughman, R.P. et al.

Baughman, Henderson, Whitsett, Gunther, Keeton, Waide, Zaccardelli, Pattishall, Rashkin,

Surfactant replacement for ventilator-associated pneumonia: a preliminary report.

BACKGROUND: Surfactant abnormalities have been described in bacterial pneumonia. OBJECTIVE: To determine the safety and effect of exogenous surfactant replacement in patients with ventilator-associated pneumonia (VAP). METHODS: Patients with VAP were randomized in a double-blind study to receive either an artificial surfactant (Exosurf) consisting mostly of disaturated phospholipids (DSPL) or saline via a continuous nebulizer system for 5 days. Patients underwent bronchoscopy and bronchoalveolar lavage (BAL) prior to and after 4 days of therapy. RESULTS: Twenty-two patients were randomized, with 8 receiving Exosurf. There was no detected difference in outcome between the saline- and Exosurf-treated patients in terms of days on ventilator, 30-day or hospital mortality. At the follow-up lavage, the patients treated with Exosurf had a significant rise in the level of DSPL (p < 0.05), while the saline group did not, suggesting delivery of drug. Also at the follow-up lavage, the percentage of neutrophils in the BAL fell in the Exosurf patients (p < 0.01), but not in the saline group. CONCLUSION: Exogenous surfactant replacement given to patients with VAP increased the amount of DSPL retrieved by BAL. This treatment was associated with a fall in the neutrophil response to pneumonia.[1]

References

Surfactant replacement for ventilator-associated pneumonia: a preliminary report. Baughman, R.P., Henderson, R.F., Whitsett, J., Gunther, K.L., Keeton, D.A., Waide, J.J., Zaccardelli, D.S., Pattishall, E.N., Rashkin, M.C. Respiration; international review of thoracic diseases. (2002) [Pubmed]

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