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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.

The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements during Caenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migration and again during cytokinesis. The Nedd8 pathway also was required after meiosis to negatively regulate katanin, a microtubule-severing complex, permitting the assembly of a large mitotic spindle. We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis.[1]

References

  1. Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Kurz, T., Pintard, L., Willis, J.H., Hamill, D.R., Gönczy, P., Peter, M., Bowerman, B. Science (2002) [Pubmed]
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