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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mutator bacteria as a risk factor in treatment of infectious diseases.

We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.[1]

References

  1. Mutator bacteria as a risk factor in treatment of infectious diseases. Giraud, A., Matic, I., Radman, M., Fons, M., Taddei, F. Antimicrob. Agents Chemother. (2002) [Pubmed]
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