Drug-induced systemic lupus erythematosus associated with etanercept therapy.
Specific antagonists of tumour necrosis factor (TNF)-alpha have rapidly gained popularity for the treatment of rheumatoid arthritis. The monoclonal antibody against TNF-alpha, infliximab, has been associated with induction of systemic lupus erythematosus ( SLE); however, there have been no published reports of drug-induced SLE associated with the soluble TNF-alpha receptor etanercept. We describe four female patients who developed signs and symptoms of SLE during treatment with etanercept; in two SLE was unambiguous. On diagnosis of SLE, etanercept was discontinued and the SLE-related symptoms promptly resolved. Etanercept should be considered in the list of agents associated with drug- induced SLE.[1]References
- Drug-induced systemic lupus erythematosus associated with etanercept therapy. Shakoor, N., Michalska, M., Harris, C.A., Block, J.A. Lancet (2002) [Pubmed]
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