Lewis acid promoted phenylseleno group transfer tandem radical cyclization reactions

Org Lett. 2002 Apr 4;4(7):1239-41. doi: 10.1021/ol025750n.

Abstract

[reaction: see text] A new Lewis acid promoted phenylseleno group transfer tandem radical cyclization method was developed. In the presence of Lewis acids such as Yb(OTf)3 or Mg(ClO4)2, under photolysis condition at low temperature (-45 degrees C), various unsaturated alpha-phenylseleno beta-keto amides underwent radical cyclization reactions to give monocyclic or bicyclic products in a highly efficient, regioselective, and stereoselective manner.