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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Klaivanolide, an antiprotozoal lactone from Uvaria klaineana.

Bioguided-fractionation of a CH(2)Cl(2) extract of the stems of Uvaria klaineana (Annonaceae) led to isolation of klaivanolide, a novel bisunsaturated 7-membered lactone (5-acetoxy-7-benzoyloxymethyl-7H-oxepin-2-one), together with benzyl benzoate. Klaivanolide showed potent in vitro antileishmanial activity against both sensitive and amphotericin B-resistant promastigote forms of Leishmania donovani with IC(50) values of 1.75 and 3.12 microM, respectively. The compound also showed in vitro trypanocidal activity against trypomastigote forms of Trypanosoma brucei brucei GVR 35. Its structure was established by 1D and 2D NMR and other spectroscopic techniques.[1]


  1. Klaivanolide, an antiprotozoal lactone from Uvaria klaineana. Akendengue, B., Roblot, F., Loiseau, P.M., Bories, C., Ngou-Milama, E., Laurens, A., Hocquemiller, R. Phytochemistry (2002) [Pubmed]
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