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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Negative co-receptors on lymphocytes.

The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7-CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1-PD-1-ligand pathway has revealed that this pathway can downregulate TCR- and CD28-mediated signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses.[1]

References

  1. Negative co-receptors on lymphocytes. Greenwald, R.J., Latchman, Y.E., Sharpe, A.H. Curr. Opin. Immunol. (2002) [Pubmed]
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