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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders.

In contrast with two previous western reports, a recent study on a Chinese population found an association for allele 12 of the variable number tandem repeat (VNTR) in the second intron of the serotonin transporter (5-HTT) gene and schizophrenic disorders. We have replicated this finding for a Chinese population in Taiwan (114 schizophrenic patients and 127 controls), demonstrating a modest but significant statistical association for the 5-HTT-VNTR allele 12 and schizophrenic patients (one-sided p = 0.043). This positive finding further supports the proposition that the 5-HTT-VNTR allele 12 is a risk factor for schizophrenic disorders in Chinese populations, although the effect is weak.[1]

References

  1. Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders. Tsai, S.J., Ouyang, W.C., Hong, C.J. Neuropsychobiology (2002) [Pubmed]
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