- Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. Reynolds, L.F., Smyth, L.A., Norton, T., Freshney, N., Downward, J., Kioussis, D., Tybulewicz, V.L. J. Exp. Med. (2002)