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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group.

The biological activity of compound 9 obtained by introducing an alpha-methylene-gamma-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.[1]

References

  1. Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group. González, A.G., Silva, M.H., Padrón, J.I., León, F., Reyes, E., Alvarez-Mon, M., Pivel, J.P., Quintana, J., Estévez, F., Bermejo, J. J. Med. Chem. (2002) [Pubmed]
 
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