How to grab a microtubule on the move.
In migrating cells, Rho family GTPases and their effectors play a central role in polarizing and in organizing the actin and microtubule cytoskeletons. A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170.[1]References
- How to grab a microtubule on the move. Brunner, D. Dev. Cell (2002) [Pubmed]
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