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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Allogeneic bone marrow transplantation: cure for familial Mediterranean fever.

We describe data on a 7-year-old girl with congenital dyserythropoietic anemia (CDA), who also had familial Mediterranean fever ( FMF). Repeated transfusions required since the age of 6 months to treat her CDA led to iron overload and a persistently high ferritin level. Her relapsing FMF made effective iron chelation therapy very difficult. Consequently, at the age of 4 years, she underwent allogeneic, sibling bone marrow transplantation (BMT). During conditioning for her BMT, symptoms of FMF, including splenomegaly, arthritis, and recurrent abdominal pain, began to resolve and she was gradually weaned off colchicine. Now, 2 years after the transplantation, she remains free from FMF symptomatology and is off all immunosuppressants. This case demonstrates that symptoms of FMF can be alleviated by the therapy used during allogeneic BMT. In this patient it is likely that the missing factor in FMF is now being provided by granulocytes derived from the stem cells within transplanted bone marrow.[1]

References

  1. Allogeneic bone marrow transplantation: cure for familial Mediterranean fever. Milledge, J., Shaw, P.J., Mansour, A., Williamson, S., Bennetts, B., Roscioli, T., Curtin, J., Christodoulou, J. Blood (2002) [Pubmed]
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