Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Malnati, M. et al.

Malnati, Broccolo, Nozza, Sarmati, Ghezzi, Locatelli, Delfanti, Capiluppi, Careddu, Andreoni, Monini, Poli, Lazzarin, Lusso, Tambussi,

Retrospective analysis of HHV-8 viremia and cellular viral load in HIV-seropositive patients receiving interleukin 2 in combination with antiretroviral therapy.

The combination of interleukin 2 (IL-2) and antiretroviral therapy (ART) represents an emerging strategy in the treatment of patients infected with HIV. Aside from its immunomodulatory role, however, IL-2 may induce replication of human herpesvirus 8 (HHV-8)/Kaposi sarcoma (KS)-associated herpesvirus. We retrospectively evaluated HHV-8 plasma viremia and cellular load, as well as anti-HHV-8 antibody titers, in sequential samples from 84 patients receiving ART alone or in combination with IL-2. At baseline, HHV-8 plasma viremia was present only in 2 HHV-8-seropositive patients in whom KS subsequently developed during or immediately after termination of IL-2 therapy. The level of viremia increased during follow-up and peaked at the time of the clinical manifestation of KS. Moreover, transient peaks of HHV-8 viremia were temporally associated with administration of IL-2. HHV-8 plasma viremia was never detected in the other 47 patients receiving IL-2 nor in 35 controls treated only with ART. Thus, IL-2 therapy seems safe in most patients infected with both HIV and HHV-8, except for those with detectable HHV-8 viremia, who may not be eligible for IL-2 treatment.[1]

References

Retrospective analysis of HHV-8 viremia and cellular viral load in HIV-seropositive patients receiving interleukin 2 in combination with antiretroviral therapy. Malnati, M., Broccolo, F., Nozza, S., Sarmati, L., Ghezzi, S., Locatelli, G., Delfanti, F., Capiluppi, B., Careddu, A., Andreoni, M., Monini, P., Poli, G., Lazzarin, A., Lusso, P., Tambussi, G. Blood (2002) [Pubmed]

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