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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Fiegl, M. et al.

Fiegl, Greil, Pechlaner, Krugmann, Dirnhofer,

Intravascular large B-cell lymphoma with a fulminant clinical course: a case report with definite diagnosis post mortem.

A patient is described who presented with pancytopenia, splenomegaly and excessively elevated lactate dehydrogenase levels in concurrence with signs of extramedullary hematopoiesis. Although initially considered in the differential diagnostic spectrum, a highly aggressive lymphoma could not be identified before the patient died, 6 weeks after admission. Even an intensive diagnostic work-up including splenectomy and repeated bone marrow biopsies was inconclusive. Finally, the diagnosis of an intravascular large B-cell lymphoma, a highly aggressive clinical subtype of a diffuse large B-cell lymphoma, spreading within vascular structures of multiple organs was established by autopsy. Intravascular large B-cell lymphoma is often not diagnosed before death due to the exclusive intravascular growth pattern of the tumor cells and a fulminant clinical course. The heterogeneous clinical features of this lymphoma subtype are discussed.[1]

References

Intravascular large B-cell lymphoma with a fulminant clinical course: a case report with definite diagnosis post mortem. Fiegl, M., Greil, R., Pechlaner, C., Krugmann, J., Dirnhofer, S. Ann. Oncol. (2002) [Pubmed]

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