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In vitro immunomodulatory activity of verbascoside from Nepeta ucrainica L.

Nepeta ucrainica L. is used as a herbal tea in Kazakhistan. Phytochemical investigations of the aerial parts of the plant resulted in the isolation of verbascoside (1) and 1,5,9-epi-deoxyloganic acid (2). The structures of the compounds were elucidated by spectral (UV, IR, (1)H-NMR and (13)C-NMR) methods and HPLC analysis. The in vitro immunomodulatory activity of verbascoside was investigated by assessing neutrophil function; chemotaxis and intracellular killing activity. Verbascoside showed an increased chemotactic activity in all doses applied compared with the medium used as a negative control and had a positive effect on respiratory burst of neutrophils, but there was an opposite effect with increasing doses, pointing to a possible suppression of neutrophil intracellular killing activity.[1]

References

  1. In vitro immunomodulatory activity of verbascoside from Nepeta ucrainica L. Akbay, P., Calis, I., Undeger, U., Basaran, N., Basaran, A.A. Phytotherapy research : PTR. (2002) [Pubmed]
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