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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antimalarial activity of yingzhaosu A analogues.

Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.[1]

References

  1. Antimalarial activity of yingzhaosu A analogues. Kim, H.S., Begum, K., Ogura, N., Wataya, Y., Tokuyasu, T., Masuyama, A., Nojima, M., McCullough, K.J. J. Med. Chem. (2002) [Pubmed]
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