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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice.

The role of IL-4 in the development of lung fibrosis is as yet unclear. Bleomycin (Bleo) or saline ( Sal) was injected intratracheally into three groups of C57BL/6J mice: transgenic animals that overexpressed IL-4 (IL-4 TG, n = 14), mice with a targeted knockout mutation of the IL-4 gene (IL-4 KO, n = 11), and wild-type (WT, n = 13) mice. At 14 days, lung fibrosis was evaluated by hydroxyproline measurement and by quantitative image analysis of fibrosis fraction and alveolar wall area fraction. Bronchoalveolar lavage cell counts in all Bleo-treated groups demonstrated an increased percentage of lymphocytes with a corresponding decrease in the percentage of macrophages. Comparing Bleo- to Sal-treated controls within each group of mice showed increases in all lung fibrosis parameters in IL-4 KO and WT, but not in any of the parameters in IL-4 TG mice. The severity of Bleo-induced fibrotic response was decreased in overexpressed IL-4 TG compared with IL-4 KO mice. These data negate a critical profibrotic role for IL-4 in Bleo-induced lung fibrosis.[1]

References

  1. Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Izbicki, G., Or, R., Christensen, T.G., Segel, M.J., Fine, A., Goldstein, R.H., Breuer, R. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
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