Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras.
Published results implicate PI3 kinase as a target of oncogenic Ras activity leading to the suppression of Fas but whether other Ras targets (e.g. Raf-1) are also involved is unclear. Here we report that thymic lymphomas overexpressing Ras and Raf-1 exhibit low expression of Fas. We show that expression of Fas in these lymphomas can be increased not only in the presence of a specific inhibitor (LY294002) of P13 kinase, but also in the presence of specific inhibitor (PD98059) of MEK, downstream target of Raf-1. Both treatments result in accumulation of ERK in cytosol of lymphoma cells suggesting cross-talk between these two pathways regulating Fas expression. Treatment with PD98059 also results in apoptosis of the lymphoma cells but not of normal thymocytes expressing low Raf-1 levels. These observations provide evidence for involvement of Raf-1/MEK/ ERK pathway in Ras- mediated inhibition of Fas expression and in selective promotion of survival of lymphoma cells.[1]References
- Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras. Kalas, W., Kisielow, P., Strzadala, L. Leuk. Lymphoma (2002) [Pubmed]
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