- BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Mayerhofer, M., Valent, P., Sperr, W.R., Griffin, J.D., Sillaber, C. Blood (2002)