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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Enantioselective reduction of trifluoromethyl ketones with chiral organomagnesium amides (COMAs).

Chiral organomagnesium amides (COMAs), readily prepared from dialkylmagnesiums and chiral secondary amines, can reduce trifluoromethyl ketones to form secondary alcohols with excellent enantioselectivities (up to 98:2 er) and chemical yields (typically >95% conversion, >85% isolated yields). These MPV-type reductions use an achiral hydride source, and the chiral amine is readily recovered. [reaction: see text][1]

References

  1. Enantioselective reduction of trifluoromethyl ketones with chiral organomagnesium amides (COMAs). Yong, K.H., Chong, J.M. Org. Lett. (2002) [Pubmed]
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