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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A short history of LIM domains (1993-2002): from protein interaction to degradation.

The LIM domain is a cysteine-rich zinc-finger motif found in a large family of proteins. In LIM-homeodomain (LIM-hd) transcription factors and LIM-only (LMO) factors, the LIM domains are responsible for key interactions with co-activators, co-repressors, competitors, and other transcription factors, and are therefore of considerable importance for the regulation of associated transcriptional activity. In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.[1]

References

  1. A short history of LIM domains (1993-2002): from protein interaction to degradation. Rétaux, S., Bachy, I. Mol. Neurobiol. (2002) [Pubmed]
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