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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Inositol 1,4,5-trisphosphate receptor/Ca(2+) channel modulatory role of chromogranins A and B.

The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A (CgA) and B (CgB). The IP(3)R/Ca(2+) channel was shown to directly interact with CgA and CgB at the intragranular pH 5.5, and this coupling led to modulation of the IP(3)R/Ca(2+) channel activity by the coupled chromogranins. These results provide the molecular structural basis of the IP(3)-mediated Ca(2+) release mechanism of secretory granules.[1]

References

  1. Inositol 1,4,5-trisphosphate receptor/Ca(2+) channel modulatory role of chromogranins A and B. Yoo, S.H., So, S.H., Huh, Y.H., Park, H.Y. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
 
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