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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A unique amino acid deletion in the chimpanzee Cyclin T1 does not affect Tat trans-activation of HIV.

We have cloned and sequenced the chimpanzee (Pan troglodytes) cyclin T1 cDNA and performed functional HIV-1 Tat trans-activation studies. A unique codon deletion leading to a deleted asparagine residue in the N-terminal region of the first cyclin domain was discovered. This mutation does not significantly change the trans-activation of HIV-1, suggesting that Tat-Cyclin T1 mediated transcription is not a major barrier to HIV replication in the chimpanzee.[1]

References

  1. A unique amino acid deletion in the chimpanzee Cyclin T1 does not affect Tat trans-activation of HIV. Rollman, E.N., Lund, L.H., Sjöstrand, D.E., Leitner, T., Wahren, B.E. AIDS (2002) [Pubmed]
 
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