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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A.

Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.[1]

References

  1. Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A. Williams, P., Chaudhry, Y., Goodfellow, I.G., Billington, J., Powell, R., Spiller, O.B., Evans, D.J., Lea, S. J. Biol. Chem. (2003) [Pubmed]
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