EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein

Biochem Biophys Res Commun. 2003 Jan 17;300(3):619-23. doi: 10.1016/s0006-291x(02)02904-2.

Abstract

The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins / genetics*
  • Databases, Protein / statistics & numerical data
  • Insecta
  • Mammals
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Neuraminidase / genetics
  • Protein Structure, Tertiary / genetics
  • Sequence Analysis, Protein
  • Sequence Homology, Amino Acid*

Substances

  • Caenorhabditis elegans Proteins
  • Membrane Proteins
  • ced-1 protein, C elegans
  • Neu1 protein, mouse
  • Neuraminidase