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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Protein expression systems for structural genomics and proteomics.

One of the key steps of structural genomics and proteomics is high-throughput expression of many target proteins. Gene cloning, especially by ligation-independent cloning techniques, and recombinant protein expression using microbial hosts such as Escherichia coli and the yeast Pichia pastoris are well optimized and further robotized. Cell-free protein synthesis systems have been developed for large-scale production of protein samples for NMR (stable-isotope labeling) and X-ray crystallography (selenomethionine substitution). Protein folding is still a major bottleneck in protein expression. Cell-based and cell-free methods for screening of suitable samples for structure determination have been developed for achieving a high success rate.[1]


  1. Protein expression systems for structural genomics and proteomics. Yokoyama, S. Current opinion in chemical biology. (2003) [Pubmed]
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