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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tracking an embryonic L1 retrotransposition event.

Long interspersed nuclear elements 1 ( L1) are active retrotransposons that reside in many species, including humans and rodents. L1 elements produce an RNA intermediate that is reverse transcribed to DNA and inserted in a new genomic location. We have tagged an active human L1 element (L1(RP)) with a gene encoding enhanced GFP ( EGFP). Expression of GFP occurs only if L1- EGFP has undergone a cycle of transcription, reverse transcription, and integration into a transcriptionally permissive genomic region. We show here that L1- EGFP can undergo retrotransposition in vivo and produce fluorescence in mouse testis. The retrotransposition event characterized here has occurred at a very early stage in the development of an L1- EGFP transgenic founder mouse.[1]

References

  1. Tracking an embryonic L1 retrotransposition event. Prak, E.T., Dodson, A.W., Farkash, E.A., Kazazian, H.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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