Role of cytokines in the development and maintenance of memory T cells during respiratory viral infection

Curr Pharm Des. 2003;9(1):51-9. doi: 10.2174/1381612033392521.

Abstract

Much progress has been made in understanding the relationship between cytokines, T cell development, and the maintenance of memory T cells by examining the immune response to respiratory viral infections. Most of these studies have examined the T cell response to viruses that cause acute infection of limited duration, and have focused on the interplay between cytokines and individual responses by T cell subsets. This reductionism approach has been useful to piece together the puzzle of the host-immune response to respiratory virus infection, and has added to the holistic view of the networks involved in homeostatic control of T cell development and maintenance. This review addresses aspects of T cell biology that constitute the response to respiratory viral infections.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cytokines / immunology*
  • Cytokines / physiology
  • Humans
  • Immunologic Memory / immunology*
  • Respiratory Tract Infections / immunology*
  • Respiratory Tract Infections / virology
  • T-Lymphocytes / immunology*
  • Virus Diseases / immunology*
  • Virus Diseases / virology

Substances

  • Cytokines