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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms.

BACKGROUND: Epidemiologic studies have shown an inverse correlation between acute coronary events and high intake of dietary vitamin E. Recent clinical studies, however, failed to show any beneficial effects of alpha-tocopherol on cardiovascular events. Absence of tocopherols other than alpha-tocopherol in the clinical studies may account for the conflicting results. OBJECTIVE: This study compared the effect of a mixed tocopherol preparation rich in gamma-tocopherol with that of alpha-tocopherol on platelet aggregation in humans and addressed the potential mechanisms of the effect. DESIGN: Forty-six subjects were randomly divided into 3 groups: alpha-tocopherol, mixed tocopherols, and control. ADP and phorbol 12-myristate 13-acetate-induced platelet aggregation, nitric oxide (NO) release, activation of endothelial constitutive nitric-oxide synthase (ecNOS; EC and of protein kinase C (PKC), and ecNOS, superoxide dismutase (SOD; EC, and PKC protein content in platelets were measured before and after 8 wk of administration of tocopherols. RESULTS: ADP-induced platelet aggregation decreased significantly in the mixed tocopherol group but not in the alpha-tocopherol and control groups. NO release, ecNOS activation, and SOD protein content in platelets increased in the tocopherol-treated groups. PKC activation in platelets was markedly decreased in the tocopherol-treated groups. Mixed tocopherols were more potent than alpha-tocopherol alone in modulating NO release and ecNOS activation but not SOD protein content or PKC activation. CONCLUSIONS: Mixed tocopherols were more potent in preventing platelet aggregation than was alpha-tocopherol alone. Effects of mixed tocopherols were associated with increased NO release, ecNOS activation, and SOD protein content in platelets, which may contribute to the effect on platelet aggregation.[1]


  1. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Liu, M., Wallmon, A., Olsson-Mortlock, C., Wallin, R., Saldeen, T. Am. J. Clin. Nutr. (2003) [Pubmed]
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