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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.

Previous observation has shown that the wild-type Kras2 allele is a suppressor of lung cancer in mice. Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas. Interestingly, all of the lung adenocarcinomas and large cell carcinomas containing a Kras2 mutation exhibited allelic loss of the wild-type Kras2 allele when a correlation between LOH of the region on chromosome 12p and Kras2 mutation was made. These results from human lung cancer tissues provide a strong evidence in support of our previous observation in mouse models that the wild-type Kras2 is a tumor suppressor of lung cancer.[1]

References

  1. LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Li, J., Zhang, Z., Dai, Z., Plass, C., Morrison, C., Wang, Y., Wiest, J.S., Anderson, M.W., You, M. Oncogene (2003) [Pubmed]
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