Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris.
BACKGROUND: Flagellate hyperpigmentation is a well-documented complication of systemic bleomycin sulfate therapy when using doses of 100 U or more as an antineoplastic agent. Two cases occurred after using systemic doses from 15 to 30 U injected intravenously or intrapleurally; however, it has not been described as a complication following intralesional treatment of verruca plantaris. OBSERVATIONS: We report a case of flagellate hyperpigmentation after intralesional injection of 14 U of bleomycin for verrucae plantaris and review the literature associated with this cutaneous complication. CONCLUSIONS: Flagellate hyperpigmentation from extremely low doses of intralesional bleomycin is a previously undescribed complication. Although the mechanisms of reaction are not clearly understood, the clinician should be mindful of this uncommon complication.[1]References
- Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris. Abess, A., Keel, D.M., Graham, B.S. Archives of dermatology. (2003) [Pubmed]
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