- Mechanism and implications of brown adipose tissue proliferation in rats and monkeys treated with the thiazolidinedione darglitazone, a potent peroxisome proliferator-activated receptor-gamma agonist. Aleo, M.D., Lundeen, G.R., Blackwell, D.K., Smith, W.M., Coleman, G.L., Stadnicki, S.W., Kluwe, W.M. J. Pharmacol. Exp. Ther. (2003)