RNA sensors and riboswitches: self-regulating messages

Curr Biol. 2003 Apr 1;13(7):R285-91. doi: 10.1016/s0960-9822(03)00203-3.

Abstract

Recent years have seen the discovery of myriad new regulatory and catalytic functions for RNA. A series of new studies have now demonstrated that certain RNA sequences can directly sense ambient temperature or any of a variety of small molecule metabolites. Remarkably, these sensors allow associated mRNAs to regulate their own transcription or translation accordingly, without the need for regulatory proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation / genetics*
  • Protein Biosynthesis / genetics*
  • RNA / metabolism*
  • Signal Transduction / genetics*
  • Temperature
  • Transcription, Genetic / genetics*
  • Vitamins

Substances

  • Vitamins
  • RNA