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Kostrouchova, M. et al.

Kostrouchova, Kostrouch, Saudek, Piatigorsky, Rall,

BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development.

bir-1, a Caenorhabditis elegans inhibitor-of-apoptosis gene homologous to Survivin is organized in an operon with the transcription cofactor C. elegans SKIP (skp-1). Because genes arranged in operons are frequently linked functionally, we have asked whether BIR-1 also functions in transcription. bir-1 inhibition resulted in multiple developmental defects that overlapped with C. elegans SKIP loss-of-function phenotypes: retention of eggs, dumpy, movement defects, and lethality. bir-1 RNA- mediated interference decreased expression of several gfp transgenes and the endogenous genes dpy-7 and hlh-1. Immunoblot analysis revealed decreased phosphoacetylated histones in bir-1 RNA-mediated interference-treated worms. In a heterologous transfection system, BIR-1 augments thyroid hormone-regulated transcription and has an additive effect with SKIP. These results show that BIR-1 functions in the regulation of transcription and development.[1]

References

BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development. Kostrouchova, M., Kostrouch, Z., Saudek, V., Piatigorsky, J., Rall, J.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]

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